Preferred Regimens for Second and Subsequent, Lines of Therapy for HR-Positive, HER2-Negative, Fulvestrant in combination with a CDK 4/6 inhibitor may, during prior treatment with AIs with or without 1 line of, prior chemotherapy (category 1), because PFS was im-, proved compared with fulvestrant alone in a phase III, The phase III trial (PALOMA-3) compared the, combination of palbociclib and fulvestrant to fulvestrant. J Clin Oncol 2016; resection of primary tumor with no surgery in stage IV breast cancer. Background: Triple-negative breast cancer (TNBC) is known for its higher recurrence rate in short-term (3-5 years) follow-up and limited systemic therapeutic methods (chemotherapy). Ann Oncol, Shaughnessy J, Loesch D, et al. Conclusions Updates in Version 1.2020 of the NCCN Guidelines for Hepatobiliary Cancers from Version 4.2019 include: UPDATES Continued The Table of Contents page was updated to reflect changes in the algorithm. 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